Coma Research Today is a free monthly online journal that collates and summarizes the latest research about Coma, including details on causes, diabetes, gcs, recovery. | ||||||
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Standardized experimental brain death model for studies of intracranial dynamics, organ preservation, and organ transplantation in the pig.Purins K, Sedigh A, Molnar C, Jansson L, Korsgren O, Lorant T, Tufveson G, Wennberg L, Wiklund L, Lewén A, Enblad P Department of Neuroscience, Section of Neurosurgery, Uppsala University Hospital, Uppsala University, Uppsala, Sweden. Published 18 February 2011 in Crit Care Med, 39(3): 512-7. Articles on Coma published 11 January 2011: Second brain death examination may negatively affect organ donation. Neurology, 76(2): 119-24. Articles on Coma published 10 January 2011: Effects of d-3-hydroxybutyrate treatment on hypoglycemic coma in rat pups. Exp Neurol, 227(1): 180-7. d-3-Hydroxybutyrate (3OHB) is an alternative energy substrate for the brain during hypoglycemia, especially in infancy. Knowledge of the capacity and limits of 3OHB to compensate for cerebral glucose depletion during hypoglycemia in developing brain is important for its potential clinical use, but is scarce. We studied the effect of 3OHB treatment during insulin-induced hypoglycemia in 13-day-old rat pups. 3OHB treatment resulted in increased 3OHB plasma levels in hypoglycemic animals (3-4mM ... [Abstract] [Full-text] Articles on Coma published 16 December 2010: Is the increase in DCD organ donors in the United Kingdom contributing to a decline in DBD donors? Transplantation, 90(12): 1506-10. Articles on Coma published 22 November 2010: Fasciculations in brain death. Crit Care Med, 38(12): 2377-8. Fasciculations in brain death. Crit Care Med, 38(12): 2377-8. Articles on Coma published 30 September 2010: Carbon monoxide inhalation decreased lung injury via anti-inflammatory and anti-apoptotic effects in brain death rats. Exp Biol Med (Maywood), 235(10): 1236-43. Brain death (BD) induces acute lung injury and makes donor lungs unfit for transplantation. Carbon monoxide (CO) inhalation at 50-500 ppm exerts anti-inflammatory and anti-apoptosis effects in several lung injury models. We examined whether CO inhalation would show favorable effects on lung injury in BD rats. BD rats inhaled 250 ppm CO for two hours. Inhalation decreased the severity of lung injury, as checked by histological examination. CO treatment reversed aggravation in PaO(2)/FiO(2), base ... [Abstract] [Full-text] Contribution of Toll-like receptor activation to lung damage after donor brain death. Transplantation, 90(7): 732-9. INTRODUCTION: Donor brain death is the first injurious event that can produce inflammatory dysfunction after pulmonary transplantation. This study was designed to determine whether stimulation of the toll-like receptor (TLR) system contributes to the changes produced by brain death. MATERIALS AND METHODS: Rats were repeatedly treated with specific agonists for TLR4 or TLR2/6 to desensitize these receptors. Brain death was then induced by inflation of a balloon catheter within the extradural ... [Abstract] [Full-text] Articles on Coma published 20 August 2010: Ethical controversies at end of life after traumatic brain injury: defining death and organ donation. Crit Care Med, 38(9): S502-9. Death is more than a mere biological occurrence. It has important legal, medical, and social ramifications that make it imperative that those who are responsible for determination of death be accurate and above suspicion. The medical and legal definitions of death have evolved to include consideration of such concepts as loss of integration of the whole organism, loss of autonomy, and loss of personhood. Development of the concept of brain death coincided with advances in medical technology ... [Abstract] [Full-text] © 2004-2011 Coma Research Today. All Rights Reserved. |
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